acyl-CoA acyl-CoA is a thiol lipid compound of fatty acids and CoA (RCO-CoA). It is an active metabolic intermediate for fatty acid synthesis and decomposition, and generates fatty acid and coenzyme A upon hydrolysis. In addition, ATP is consumed during the synthesis of fatty acids and coenzyme A.
Acyl-CoA acyl-CoA is involved in the synthesis of fatty acid chain lengths and has at least three enzymes with different specificities (acetyl-CoA synthetase, EC 6.2.1.1.. Butyryl-CoA synthase, EC 6.2.1.2 acts on C4-Cll. Acyl-CoA synthetase, EC 6.2.1.3 acts on C6-C20).
long-chain acyl-CoA synthetase (long-chain acyl-Co A synthase, ACSL) is A member of the acyl-activating enzyme family, which contains five different subtypes and is encoded by different genes. They mainly catalyze fatty acid synthesis of fatty acyl-CoA between 12 and 20 carbon chains, which is the first step of triglyceride synthesis and fatty acid β oxidation in the body.